The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in the areas of telomerase biology. These contribtuions include finding a high frequency of TERT promoter mutations (Clin Cancer Res. 2014 20(18):4935), the impact of these TERT mutations on TERT expression, and the clinical relevance of these mutations in patients (Science. 2015;347(6225):1006). Further discoveries have been made in TERT regulation (Genes Dev. 2015 29(21):2219). We are seeking a highly motivated individual to further develop this work as well as discover and investigate the role of TERT, its regulators and effectors, in cancer progression and metastasis. In addition, the laboratory has ongoing drug discovery projects directed at key molecules involved in telomerase biology which may interest the individual. The successful candidate will have a PhD degree and background in telomerase biology or related field as well as in functional genomics (including CRISPR, shRNA and cDNA library use), signal transduction and biochemistry/chemistry or related fields. We welcome applications who are completing their PhD as well as individuals seeking additional postdoctoral training. Strong preference will be given to individuals with an outstanding publication record from their prior graduate and/or postgraduate training and/or existing extramural funding.
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:
May assist in preparation of grant proposals, but is not responsible for generating grant funds.
Participates in publications and presentations as author or co-author.
Designs and performs experiments. Keeps detailed experimental records and documentation and analyze the results with the Principal Investigator.
Develops, adapts, and implements new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
Meets with Dr. Theodorescu on a regular basis to discuss research progress and plans.
May be asked to write small grant proposals or NRSA/T32 applications.
Spends about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research.
Since its beginning in 1902, Cedars-Sinai has evolved to meet the healthcare needs of one of the most diverse regions in the nation, continually setting new standards in quality and innovation in patient care, research, teaching and community service. Today, Cedars-Sinai is widely known for its national leadership in transforming healthcare for the benefit of patients.Cedars-Sinai is one of the largest nonprofit academic medical centers in the U.S. with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Clinical programs range from primary care for preventing, diagnosing and treating common conditions to specialized treatments for rare, complex and advanced illnesses. In addition, Cedars-Sinai serves the community through its Medical Network, which includes the highly rated Cedars-Sinai Medical Group and Cedars-Sinai Health Associates. Cedars-Sinai has consistently been named one of America’s Best Hospitals by U.S. News & World Report, has received the National Research Corporation’s Consumer Choice Award 18 years in a row for providing the highest quality medical care in Los Angeles, and has the longest running Magnet desig...nation for nursing excellence in California. Cedars-Sinai is a leader in the clinical care and research of heart disease, cancer and brain disorders, among other areas. Pioneering research achievements include using cardiac stem cells to repair damaged hearts, developing minimally invasive surgical techniques and discovering new types of drugs to target cancer more precisely. Cedars-Sinai also impacts the future of healthcare through education programs that encompass everything from highly competitive medical residency and fellowship programs to a biomedical science and translational medicine PhD program, advanced training for nurses and educational opportunities for allied health professionals. Most notably, Cedars-Sinai demonstrates a longstanding commitment to strengthening the Los Angeles community through wide-ranging programs that improve the health of its most vulnerable residents.